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an we expect to find anything but unpleasant and unusual reactions under such
circumstances? I regret to say that such conditions have been standard for almost all the research that has
(11 of 16)4/15/2004 7:02:54 AM
On Being Stoned - Chapter 2
been done on marijuana intoxication or studies of other psychedelic drugs.
Indeed, practically all the conditions outlined in Table 2-1 as maximizing the probability of a "bad
trip" are standard conditions in laboratory studies of marijuana. This was not a result of deliberate
malice on the part of earlier investigators, of course, but stemmed from inadequate knowledge of the
importance of non-drug factors and from the pervasive belief in "pure" drug effects.
Future experimental studies of marijuana intoxication should note the importance of the many
controlling factors discussed above and report their values in particular studies. If this is done, we may
begin to round out our overall picture of marijuana intoxication. Further, these controlling factors should
be systematically varied. Different environments, varying from cold and sterile to warm and esthetically
pleasing along various dimensions, can be tried. Experimenters and experimental personnel can be
deliberately selected in terms of their personal attitudes toward drug use in order to assess how
important this parameter is, and so on.
On a very practical note, political pressure is now very strong for scientists to produce better
knowledge about the effects of marijuana in order to guide changes in legislation. If experimental results
are to be socially relevant, priority must be given to studies carried out under conditions comparable to
the ordinary use of marijuana today. Overdosing a naive person under very stressful conditions is not
very relevant to answering questions about the dangers of marijuana, for an overdose of multitudes of
common substances under stressful conditions can produce adverse effects. Experimental research can
be both valid and relevant. I hope it will be.
The previous scientific literature on marijuana intoxication, then, generally represents sets of
conditions under which an extremely limited range of potential effects is likely to emerge. This set of
potential effects is quite unrepresentative of the effects ordinarily associated with marijuana intoxication.
The old research literature can be of some scientific value in detailing the effects of marijuana on people
under conditions of high stress.
THE PRESENT STUDY
The present study is intended to begin to provide answers to the first, second, and fourth questions
discussed earlier under the general question of how do we scientifically study marijuana intoxication.
That is, it is intended to investigate: (1) the range of effects associated with marijuana intoxication under
its usual conditions of use; (2) the importance of such effects in terms of which effects are frequent and
which infrequent; and (3) the relationships of these effe
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